INDIANAPOLIS — Andrew Luck ran 19 yards for the winning touchdown, giving the Indianapolis Colts their first opening-day win since 2009, a 21-17 comeback victory over the Oakland Raiders.
Luck was 18 of 23 for 178 yards with two touchdown passes, but earned his eighth career fourth-quarter comeback by scrambling for a score with 5:20 to go.
Oakland started Terrelle Pryor at quarterback ahead of Matt Flynn. Pryor was 19 of 29 for 217 yards and one TD, and he broke the Raiders’ rushing record for a quarterback with 13 carries for 112 yards.
But he also threw two interceptions in the red zone, the second coming with 25 seconds left.
PATRIOTS 23, BILLS 21: In Orchard Park, N.Y., Stephen Gostkowski hit a 35-yard field goal with 5 seconds left to send New England to the road win.
Tom Brady set up the decisive score by leading a 49-yard, 12-play drive during which he twice completed passes to convert third downs. It was Brady’s 36th career victory in which the Patriots were tied or trailed in the fourth quarter.
Brady finished 29 of 52 for 288 yards two touchdowns.
The new-look Bills nearly pulled off a stunning upset in the first game under coach Doug Marrone and rookie quarterback EJ Manuel, who completed 18 of 27 passes for 150 yards and two touchdowns.
RAMS 27, CARDINALS 24: In St. Louis, Greg Zuerlein kicked a 48-yard field goal with 40 seconds left as the St. Louis Rams completed a fourth-quarter comeback.
Larry Fitzgerald caught two touchdown passes from new quarterback Carson Palmer and the Arizona defense scored one touchdown.
The Cardinals, under new coach Bruce Arians, had an 11-point lead after Fitzgerald’s 24-yarder late in the third quarter.
Jared Cook had two touchdown catches in his Rams debut. The tight end fumbled a potential third TD, a 55-yarder that would have opened the scoring, when rookie Tyrann Mathieu punched the ball free at the 8 and the play resulted in a touchback.
CHIEFS 28, JAGUARS 2: In Jacksonville, Fla., Alex Smith threw two early touchdown passes, Kansas City’s defense dominated all day and the Chiefs began the Andy Reid era with a victory at Jacksonville.
Jamaal Charles ran for 77 yards and a touchdown before leaving the game with a quadriceps injury, but that was about the only negative for the Chiefs.
The Jaguars advanced past their own 36-yard line just once — a stunning display of offensive futility in their first game under new coach Gus Bradley.
BEARS 24, BENGALS 21: In Chicago, Jay Cutler passed to Brandon Marshall for the go-ahead touchdown in the fourth quarter, helping Chicago get the victory in Marc Trestman’s coaching debut with the team.
It wasn’t quite the display the Bears were looking for after making some big changes in the offseason. But it was good enough.
The Bengals were up 21-17 early in the fourth quarter when Tim Jennings jarred the ball from Mohamed Sanu following a reception and made the recovery.
Chicago took over at its 19 and got an 8-yard run from Matt Forte on fourth-and-inches at the Bengals 27 to keep the drive going. Cutler then found Marshall in the front corner of the end zone for a 19-yard touchdown, giving Chicago a 24-21 lead with 7:58 remaining.
LIONS 34, VIKINGS 24: In Detroit, Reggie Bush turned a short pass into a 77-yard touchdown in the third quarter and finished with 191 yards of offense to help Detroit pull away from Minnesota.
Matthew Stafford was 28 of 43 for 357 yards with two TDs. His last score was a 1-yard lob to rookie tight end Joseph Fauria that sealed the win.
Adrian Peterson ran for a 78-yard TD on his first carry and scored on a 4-yard run to give Minnesota a 14-6 lead in the second. He ended up with 93 yards rushing.
TITANS 16, STEELERS 9: In Pittsburgh, Tennessee’s revamped defense sacked Ben Roethlisberger five times and the Titans shut down the Steelers.
Chris Johnson ran for 70 clock-chewing yards, Jackie Battle bulled his way to a 3-yard touchdown in the second quarter, and Rob Bironas kicked three field goals for the Titans.
Pittsburgh managed just 195 total yards and lost a series of players to injury — including Pro Bowl center Maurkice Pouncey, who left with a right knee injury and likely will miss an extended amount of time.
The Titans gave up more points than any team in the NFL last season and brought in Gregg Williams as an assistant. Roethlisberger completed 21 of 33 passes for 191 yards and a late touchdown.
DOLPHINS 23, BROWNS 10: In Cleveland, Ryan Tannehill passed for 272 yards and a touchdown, leading the Dolphins to a win over the Browns, who fell to 1-14 in Week 1 since 1999.
Tannehill, who was given more offensive weapons for his second NFL season, threw a 34-yard TD pass to Brian Hartline in the third quarter and drove the Dolphins to a game-clinching TD in the fourth. Daniel Thomas had a 1-yard scoring plunge with 6:48 left.
Miami’s Cameron Wake had 2½ sacks and the Dolphins sacked Brandon Weeden six times. Weeden threw three interceptions, and the Browns never got anything going in coach Rob Chudzinski’s debut.